Cuba Gooding Jr.

Mikey

Helen Mirren

Rose

Vanessa Ferlito

Vicki

Macy Gray

Neisha

Joseph Gordon-Levitt

Dr. Don

Stephen Dorff

Clayton Mayfield

Mo'Nique

Precious

Tom Pasch

Andrew

Ryan Eric Speise

Anthony - Age 3

Matt Higgins

Eddie

John Panzarella

Man in Hotel

Marvina Vinique

Mikey's Mother

Marilyn Yoblick

Real Estate Agent

Cullen Flynn Clancy

Anthony - age 7

Shaun Brewington

Little Mikey

Darnell Williams

Mikey's Father

Noel Murano

A.J.

Angel Oquendo

Lamar

Tomy Dunster

Gerard

Jack Krizmanich

Tommy